Diagnostic Accuracy of Frozen Section in Comparison With Fine Needle Aspiration Cytology in Thyroid Lesions – A Prospective Study
نویسندگان
چکیده
Background and Objectives: Thyroid gland because of its superficial location is amenable to direct physical examination. Clinical assessment of thyroid lesions by means of physical examination, thyroid scans and ultrasonography is not completely reliable. Fine needle aspiration cytology (FNAC) is the most cost-effective, safe and an initial diagnostic test in the pre-operative evaluation of thyroid lesions. Many surgeons use intraoperative frozen section biopsies to confirm the diagnosis of FNAC and guide the extent of thyroidectomy. Therefore, the objective of the present study was to assess the diagnostic accuracy of frozen section in comparison with fine needle aspiration cytology and histopathology in thyroid lesions. Materials & Methods: Fine needle aspiration cytology and frozen section (FS) were evaluated in 59 patients. FNAC was classified as benign, malignant and suspicious, and FS was classified as benign, deferred and malignant. Sensitivity, specificity, positive predictive value, negative predictive value and accuracy were calculated for both FS and FNAC. Results: Out of 59 patients, 3 were positive for malignancy, 51 were benign, and five were suspicious on FNAC. Over all accuracy of fine needle aspiration cytology was 93%. Five were positive for malignancy, 50 were benign and 4 were “deferred” in frozen section. Over all accuracy of frozen section was 96%. Discussion: Fine needle aspiration cytology can be used primarily to select patient for surgery and frozen section can be employed to plan the extent of surgery. Frozen section had a good accuracy, sensitivity and negative predictive value compared to fine needle aspiration cytology.
منابع مشابه
Diagnostic Accuracy of Frozen Section in Comparison With Fine Needle Aspiration Cytology in Thyroid Lesions – A Prospective Study
Background and Objectives: Thyroid gland because of its superficial location is amenable to direct physical examination. Clinical assessment of thyroid lesions by means of physical examination, thyroid scans and ultrasonography is not completely reliable. Fine needle aspiration cytology (FNAC) is the most cost-effective, safe and an initial diagnostic test in the pre-operative evaluation of thy...
متن کاملEvaluating the accuracy of fine needle aspiration and frozen section based on permanent histology in patients with follicular lesions
Background: Fine needle aspiration (FNA) has led to a decrease in unnecessary surgeries for thyroid nodules. This study was designed to compare diagnostic value of FNA and frozen section methods in the follicular lesions. Methods: This is a cross-sectional study based on the medical records of 42 patients who were referred to surgery clinic of Rasool-e-Akram hospital in Tehran with complain...
متن کاملThe diagnostic value of fine needle aspiration in comparison with frozen section in thyroid nodules: A 20-year study
Background: Fine needle aspiration (FNA) is the most important method in the diagnosis of thyroid nodules before surgery. Recently, the efficiency of FNA in thyroid nodule management has been debatable. On the other hand, intraoperative frozen section (FS) has been used to confirm the diagnosis of FNA and select the proper surgical approach. In this regard, the present study aimed to assess the...
متن کاملDiagnostic Fine Needle Aspiration in a Case of Riedel’s Thyroiditis
In Riedel’s thyroiditis, a rare chronic inflammatory disease of thyroid gland, fine needle aspiration is usually non-diagnostic because most often only follicular cells are obtained and not the fibrous material characteristic of this type of thyroiditis. Therefore the diagnosis is often only established by histopathologic study of the surgically obtained biopsy. The illustrated case is a 46-yea...
متن کاملFine Needle Aspiration Cytology of Intraocular, Orbital and Eyelid Lesions
Background: Fine-Needle Aspiration Cytology (FNAC) is used for diagnosis of intraocular, orbital and eyelid lesions. In this study we evaluated the outcome and the accuracy of using this technique in diagnosis of benign or malignant behavior of lesions. Methods: FNAC was performed on 26 specimens obtained from 25 patients with intraocular, orbital and eyelid tumors and the results were compared...
متن کامل